Var köpa Round-up Alternativ

[Mattias]

Hej,

Tänkte jag skulle prova Round-up mot lite ogräs i trädgården. Vilka butiker säljer Round-up?

[Piccante]

Nu hittar inte jag det jag läste om grodyngel, typiskt när man letar efter något... Men jag hittade en studie på råttor:

"Comparative effects of the Roundup and glyphosate on mitochondrial oxidative phosphorylation

Francisco PeixotoCorresponding Author Contact Information, E-mail The Corresponding Author

Departamento de Química, Universidade de Trás-os-Montes e Alto Douro, 5001 Vila Real, Portugal

Received 7 September 2004; revised 24 February 2005; accepted 16 March 2005. Available online 26 April 2005.


Abstract

The potential toxicity of the herbicide Roundup and its fundamental substance (glyphosate) was tested in bioenergetic functions of isolated rat liver mitochondria. Roundup stimulates succinate-supported respiration twice, with simultaneous collapse of transmembrane electrical potential, while glyphosate used in the same concentrations does not induce any significant effect. Additionally, Roundup depresses state 3 respiration by about 40%, at 15 mM, whereas uncoupled respiration in the presence of FCCP is depressed by about 50%. Depression of uncoupled respiratory activity is mediated through partial inhibition of mitochondrial complexes II and III, but not of complex IV. The phosphorylative system was affected by both a direct and an indirect effect on the F0F1 ATPase activity. The addition of uncoupled concentrations of Roundup to Ca2+-loaded mitochondria treated with Ruthenium Red resulted in non-specific membrane permeabilization, as evidenced by mitochondrial swelling in isosmotic sucrose medium. Therefore, the uncoupling of oxidative phosphorylation is also related to the non-specific membrane permeabilization induced by Roundup. Glyphosate alone does not show any relevant effect on the mitochondrial bioenergetics, in opposition to Roundup formulation products. The differences in the toxicity observed could be either attributed to some products of Roundup or to a synergic effect of glyphosate and formulation products. Bearing in mind that mitochondria is provided with a variety of bioenergetic functions mandatory for the regulation of intracellular aerobic energy production and electrolyte homeostasis, these results question the safety of Roundup on animal health.

Keywords: Roundup; Glyphosate; Mitochondrial bioenergetics; Oxidative phosphorilation; Mitochondrial permeability transition".



Tyvärr kan jag inte få tillgång till artikeln i fulltext så jag vet inte hur studien genomfördes eller vilka koncentrationer råttan utsattes för. Eller om råttor ens kan exponeras för de koncentrationerna på naturlig väg???